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In healthy adults, a major pulse of growth hormone release typically occurs shortly after falling asleep, in temporal association with the first period of slow-wave sleep, also known as deep sleep
The clinical significance of the VMAT transporters is evidenced by the fact that variants in VMAT1 have been found to be associated with susceptibility for schizophrenia and bipolar depression
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It is now recognized that several (e.g., 58) independent or interdependent events of mixed activation of oncogenes and inactivation of tumor suppressor genes are necessary to generate a malignant tumor (Hanahan and Weinberg, 2001)
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